Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid

Yusuke Sekiguchi; Tetsuko Nakaniwa; Takayoshi Kinoshita; Isao Nakanishi; Kazuo Kitaura; Akira Hirasawa; Gozoh Tsujimoto; Toshiji Tada

doi:10.1016/j.bmcl.2009.04.076

Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2920-3. doi: 10.1016/j.bmcl.2009.04.076. Epub 2009 Apr 22.

Authors

Yusuke Sekiguchi¹, Tetsuko Nakaniwa, Takayoshi Kinoshita, Isao Nakanishi, Kazuo Kitaura, Akira Hirasawa, Gozoh Tsujimoto, Toshiji Tada

Affiliation

¹ Graduate School of Science, Osaka Prefecture University, Sakai, Osaka, Japan.

PMID: 19414254
DOI: 10.1016/j.bmcl.2009.04.076

Abstract

We determined the 2.35-A crystal structure of a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds. This structural information may support discovery of potent CK2 inhibitors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate / chemistry
Binding Sites
Casein Kinase II / antagonists & inhibitors*
Casein Kinase II / chemistry*
Casein Kinase II / metabolism
Catalytic Domain
Crystallography, X-Ray
Ellagic Acid / chemistry*
Enzyme Inhibitors / chemistry*
Humans
Protein Structure, Tertiary

Substances

Enzyme Inhibitors
Ellagic Acid
Adenosine Triphosphate
Casein Kinase II